Magnesium is the second most abundant intracellular cation after potassium and fourth cation in the body overall. It takes part in a variety of processes from maintaining ionic gradients to mitochondrial breathing and DNA synthesis. Due to overall industrialisation and changes in soil mineral content RDI is hardly reached in most of the population. Estimated clinically significant magnesium deficiency might reach 15%, while subclinical might be as high as 30%.
Several meta analysis [2,3] have done a robust analysis of earlier published studies on magnesium and risks of major life threatening conditions. With over 60 single studies included in analysis data represents follow up of over one million participants. 22% reduction of risk of heart failure and 7% reduction of risk of stroke was observed per every 100 mg/day intake of magnesium (both from food and supplements). For the same dosage linear decrease is observed for all-cause and cancer mortality, 6% and 5% respectively.
Longevica discovery is very much connected to magnesium levels, being the number most common divalent cation in the body, magnesium levels are tightly connected with heavy metals transport across the membrane. In fact adequate levels of magnesium throughout lifespan might exhibit protective properties against cadmium accumulation.
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